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Others report an apo E-enriched very low density HDL fraction that represents a minor subclass (12).

As intact lipoprotein particles cannot cross the blood–brain barrier, the synthesis, remodeling, and redistribution of lipids in the brain must take place in this compartment.

Val and her husband went to Couples Negril, Jamaica in November 2015 to renew t40th-anniversary wedding vows.CSF lipoproteins induced a significant cholesterol efflux from cultured rat astrocytes, suggesting that they play an active role in maintaining the cholesterol homeostasis in brain cells. Some reports link the development of AD with lipid metabolism in the brain: lipid concentrations, especially that of fatty acid and phospholipids and to a lesser extent cholesterol, which are reduced in the CSF of AD patients (16). Its most important functions are to redistribute lipids needed for neurite growth through receptor-mediated uptake and to interact with the amyloid β peptide (4–7).Other reports show that a reduction in brain tissue membrane lipids (gangliosides, phospholipids, and cholesterol) is correlated with reduced synaptic function in patients with early onset form (EOAD) Alzheimer's disease, independent of the β amyloid depositions (17).Apo E and apo A-I are the major CSF apolipoproteins, which are present in high density lipoproteins (HDL), while apo B-containing very low or low density lipoproteins (VLDL or LDL) were never identified in CSF. (4) and later reports by Borghini et al (10) suggest that apo E-enriched HDL is the predominant lipoprotein in CSF.




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